A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
نویسندگان
چکیده
Bacillus subtilis YdhG lacks sequence homology, but demonstrates structural and functional similarity to the frataxin family, supporting a general cellular role for frataxin-type proteins in cellular iron homeostasis.
منابع مشابه
Frataxin, a molecule of mystery: trading stability for function in its iron-binding site.
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Frataxin, a highly conserved protein found in prokaryotes and eukaryotes, is required for efficient regulation of cellular iron homeostasis. Humans with a frataxin deficiency have the cardio- and neurodegenerative disorder Friedreich's ataxia, commonly resulting from a GAA trinucleotide repeat expansion in the frataxin gene. While frataxin's specific function remains a point of controversy, the...
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 5 شماره
صفحات -
تاریخ انتشار 2010